Wales had to settle for a draw against 14-man Argentina after a tense Principality Stadium encounter finished 20-20.
Pumas full-back Juan Cruz Mallia was sent off for a dangerous high challenge on Wales scrum-half Kieran Hardy after 29 minutes.
But Argentina led until 10 minutes from time before they were undone by substitute scrum-half Tomos Williams’ try that his fellow replacement Jarrod Evans converted, although Evans missed a long-range penalty to win it during the closing seconds.
Evans also added the extras to lock Will Rowlands’ touchdown, while Callum Sheedy kicked two penalties, with flanker Pablo Matera and centre Jeronimo de la Fuente touching down for Argentina, and Nicolas Sanchez booted two penalties and two conversions.
Given that Wales were minus 10 players on British and Irish Lions duty in South Africa, it was a battling display against a team that beat New Zealand and drew twice with Australia last year.
But there will also be a sense of frustration that they could not capitalise on Argentina’s indiscipline ahead of the teams meeting again in Cardiff next Saturday.
Cardiff wing Owen Lane made his first Wales appearance since the 2019 World Cup, replacing Tom Rogers among three changes following a 68-12 victory over Canada last weekend.
Elsewhere, Hallam Amos took over from an injured full-back Leigh Halfpenny and Hardy was handed a start instead of Williams.
The game had been due to take place in South America, but the coronavirus pandemic meant it was switched to Wales, with Argentina as the home side.
Argentina exerted early pressure, but Wales stirred through a powerful midfield break from number eight Aaron Wainwright, before Sheedy drifted a long-range penalty attempt narrowly wide.
Sheedy’s opposite number Sanchez then opened the scoring with a penalty, yet Wales continued to offer some bright attacking moments, with Amos lively and Lane hungry for work.
Sheedy found the target from close range with an 18th-minute strike to level things up, before Wales suffered a blow when Wainwright’s afternoon ended early in the second quarter.
The Dragons forward departed injured, being replaced by Josh Turnbull, but Wales continued to show plenty of attacking verve ahead of Sheedy kicking a second successful penalty.
The Pumas had plenty of possession and looked to patiently go through phase-play, only for them to be hit by an injury setback as wing Santiago Carreras was forced off.
Referee Matthew Carley then lost his patience following the latest in a series of collapsed scrums, sin-binning Wales prop Dillon Lewis and the tighthead’s opposite number Nahuel Tetaz Chaparro.
Matters then deteriorated for Argentina, who were briefly reduced to 13 men when Cruz Mallia was dismissed for his challenge on Hardy, handing Wales a significant advantage.
Cerdyn coch i'r Ariannin 🟥
Y cefnwr Juan Cruz Mallia yn cael ei yrru o'r cae yn dilyn tacl uchel a pheryglus ar Kieran Hardy.
🏉29' Yr Ariannin 3-6 Cymru
🏴v🇦🇷@WelshRugbyUnion
📺 @S4C @S4Cchwaraeon
💻 https://t.co/epG9jcvuNA
📍 Stadiwm Principality pic.twitter.com/LGvexK84Up— Clwb Rygbi (@yclwbrygbi) July 10, 2021
But Wales could not make it count as Sanchez hauled Argentina level with his second penalty five minutes before half-time.
And Argentina punished them as the seconds ticked down, with Matera rounding off a spell of concerted pressure as Chaparro rejoined the action, and Sanchez’s conversion opening up a 13-6 interval lead.
Argentina made a dream start to the second period when de la Fuente finished off a slick move, with Sanchez converting, and Wales head coach Wayne Pivac began making changes.
He had already sent on Saracens centre Nick Tompkins for Willis Halaholo, then he quickly followed that switch by replacing Sheedy with Evans.
Wales had to find another gear, and after they put a sustained spell together, Rowlands crashed over for his second try in successive Tests, and Evans’ conversion narrowed the gap to seven points.
Sanchez then missed two penalties in quick succession, and the game remained finely-balanced entering its final quarter.
Williams then pounced from close range, with Evans converting his half-back partner’s try to set up a grandstand finish, before Evans sent a last-gasp penalty wide.
In a fast-paced and exciting game, New Zealand found things very different to last week,
In a hard-fought and evenly contested battle, France held the lead for the entire game but Australia kept their nerve and pounced on an error from the visitors ― who did not put the ball into touch from a lineout after the final hooter ― and after winning a penalty, Lolesio clinched the triumph with the match-winning kick.
England were missing their British and Irish Lions contingent but Eddie Jones’ men did enough to overcome the visitors, despite a frustrating second half.
With seven of their contingent on British and Irish Lions duty and captain Johnny Sexton, plus Keith Earls and Cian Healy, rested, there was a fresh look to the hosts in their first meeting against Japan since the 2019 World Cup.
The Six Nations champions ran in 10 tries, although victory came at a cost after full-back Leigh Halfpenny’s 100th Test for Wales and the British and Irish Lions lasted just two minutes before he was carried off injured.
As the scoreline suggests, this was an easy outing for the men in black with Will Jordan leading the way with five tries and Brad Weber was next best with a hat-trick.
It wasn’t a vintage performance as there were signs of rustiness from the Boks, who were playing their first game since their triumphant 2019 World Cup campaign, but they improved as the match progressed and eventually outscored the Lelos six tries to none.
The Wales forwards departed inside the opening 21 minutes but it was the serious injury suffered by tour captain Jones that caused the greatest alarm as he was escorted from the pitch.
France needed to score four tries and beat Scotland by 21 points to deny Wales the title but the visitors stunned their hosts with a superb victory.
Les Bleus had lock Paul Willemse sent off 11 minutes from time for making contact with the eye area of Wales prop Wyn Jones, while the visitors played the last eight minutes with 13 men following yellow cards for Taulupe Faletau and Liam Williams, and ultimately could not hold out.
The highlight of Ireland’s most impressive outing since Andy Farrell took charge after the 2019 World Cup was Jack Conan’s try that concluded 23 phases of highly polished play.
Skipper Stuart Hogg admitted ahead of the game he was feeling nervous about standing-in for the injured Finn Russell at fly-half.
The Dark Blues needed to turn around a woeful run that had included just one win in 10 against the Irish if they were to cling on to hopes of catching frontrunners Wales.
Les Blues led 20-16 until the 76th minute when Maro Itoje bulldozed over the whitewash from short range and with Owen Farrell rifling over the conversion, they had edged the tournament favourites.
The unbeaten tournament leaders reeled off a third successive bonus-point victory to increase pressure on their rivals for silverware.
While Wales wrapped up the first major silverware of head coach Wayne Pivac’s reign in bonus-point fashion, his opposite number Eddie Jones saw England’s title hopes reduced to ruins.
Scores from Garry Ringrose, Hugo Keenan, CJ Stander and Keith Earls, plus a brace for Will Connors, helped the Irish bounce back from defeats to Wales and France in emphatic fashion.
The Irish suffered successive losses at the start of a Six Nations campaign for the first time following scores from Charles Ollivon and Damian Penaud, plus five points from the boot of Matthieu Jalibert.
Gregor Townsend’s team were looking to build on last week’s historic Twickenham victory over England and got off to the perfect start with tries from Darcy Graham and Stuart Hogg.
Willis’ left knee was damaged when he was cleared out at a ruck, just moments after the replacement flanker had scored the fifth of England’s six tries.