Samoa made it two wins from two in South Africa after hammering a poor Italy 39-10 in Nelspruit on Saturday.
The Italian scrum was their only source of a joy in a dire performance, with Samoa holding firm in defence and also excelling in open play by racking up several long-range tries.
Central to their efforts was Paul Williams, the Stade Français back scoring the points off the tee and also crossing for the game's first try.
The Islanders only held a slender lead at half-time but were irrepressible in the second half, scoring four tries and sending a message to South Africa ahead of their encounter next weekend.
Samoa impressed with their 27-17 victory over Scotland last weekend in Durban, the threats out wide of Alapati Leiua and Alesana Tuilagi bagging the tries as the Islanders underlined that they can compete with the top sides.
Italy on the other handed started brightly against the Springboks before fading dramatically in the second half, ultimately beaten comfortably 44-10.
A scoreless opening quarter dominated by issues at the scrum was eventually punctured by a try from Williams after the initial break from Tusi Pisi and Leiua put the Islanders in front.
Orquera responded with a penalty, recovering from his earlier miss to put Italy on the board as Jacques Brunel's side looked to use the full width of the pitch to try and stretch the Samoan defence.
Williams added a penalty to keep the Samoans out in front, with referee Craig Joubert repeatedly addressing both sides for indiscipline throughout the first half.
A knock to the face of Sergio Parisse gave Italy cause for concern after the captain was taken out at the ruck, the big boot of Gonzalo Garcia unable to add another three points as his penalty attempt from the other side of halfway trickled under the posts.
Sustained pressure from Samoa inside the Italian 22 then resulted in more points before half-time — Parisse penalised for not rolling away but Williams missed his second penalty attempt to the right of the posts.
A calamitous pass from Jeremy Su'a put Samoa back under pressure in their own half but Gonzalo Canale was unable to control the ball as he hacked on towards the try line. Pisi recovered to clear and keep Samoa 10-3 ahead at the break.
Samoa though wasted no time after the interval — winning possession and a clever kick in behind from Pisi had the Italians scrambling, Leiua with the pace and the bounce to score in the corner.
Parisse was full of tricks and skill for the Italians but Samoa always looked like they could produce more in attack, stretching Italy defensively and forcing penalties both on the ground and for offside.
A long-range penalty from Williams added to his and Samoa's tally to open up a 15-point lead for the Samoans, before it increased minutes later.
Italy struggled to maintain possession at the breakdown all game and Pisi pounced, spotting the space and releasing London Irish star Ofisa Treviranus who fed Johnny Leota for Samoa's third try.
Samoa then snatched a fourth try as the outstanding Ole Avei dubiously offloaded with his feet near to the touchline to feed Newcastle's Taiasina Tuifua.
Italy's one strength did pay off when their scrum created a penalty try, Leiua sent to the sin-bin moments before for infringing at the breakdown.
The Samoans rightly however had the final say, late call-up Brando Va'aulu speeding away for the fifth try after jinking around the Azzurri defence and sealing a 39-10 victory.
The scorers:
For Samoa:
Tries: Williams, Leiua, Leota, Tu'ifua, Va'aulu
Cons: Williams, Anufe
Pens: Williams 2
For Italy:
Try: Penalty
Con: di Bernardo
Pen: Orquera
Samoa:15 Brando Vaaulu, 14 Alapati Leiua, 13 Paul Williams (capt), 12 Johnny Leota, 11 Alesana Tuilagi, 10 Tusi Pisi, 9 Jeremy Sua, 8 Taiasina Tuifua, 7 Jack Lam, 6 Ofisa Treviranus, 5 Daniel Leo, 4 Teofilo Paulo, 3 Census Johnston, 2 Wayne Ole Avei, 1 Sakaria Taulafo.
Replacements: 16 Ti'i Paulo, 17 Logovii Mulipola, 18 James Johnston, 19 Kane Thompson, 20 Junior Poluleuligaga, 21 Ki Anufe, 22 Seilala Mapusua, 23 Piula Faasalele.
Italy:15 Andrea Masi, 14 Giovanbattista Venditti, 13 Gonzalo Canale, 12 Gonzalo Garcia, 11 Tommaso Iannone, 10 Luciano Orquera, 9 Edoardo Gori, 8 Sergio Parisse (c), 7 Mauro Bergamasco , 6 Alessandro Zanni, 5 Marco Bortolami, 4 Valerio Bernabo, 3 Martin Castrogiovanni 2 Leonardo Ghiraldini, 1 Alberto De Marchi.
Replacements:16 Andrea Manici, 17 Michele Rizzo, 18 Lorenzo Cittadini, 19 Antonio Pavanello, 20 Manoa Vosawai, 21 Tobias Botes , 22 Alberto di Bernardo, 23 Luke Mclean,
Referee: Craig Joubert (South Africa)
Assistant referees: John Lacey (Ireland), Tiaan Jonker (South Africa)
Television match official: Gerrie Coetzee (South Africa)
Assessor: Nigel Williams
The two sides will meet again next weekend in New Plymouth with France unable to overtake New Zealand's unassailable 2-0 lead, which came after a comfortable victory over their fellow 2011 Rugby World Cup finalists.
The hosts' win — their first ever triumph over Wales — is sweet revenge after they suffered a narrow 22-18 loss to their opponents in Osaka last Saturday and secures them a 1-1 draw in the series.
Stuart Lancaster's side stormed out of the blocks in the opening 40 minutes to rack up tries through David Strettle, Billy Twelvetress and Ben Morgan — the latter pair particularly impressive throughout on their return to Test rugby.
The USA proved to be stubborn opposition in Houston as they kept the scoreline close throughout.
A clinical South Africa got their 2013 international season up and running with a five-try 44-10 victory over Italy at Kings Park in Durban on Saturday.
The visitors were oustcored two tries to one but a big second half saw them come from behind to snatch victory in the last quarter.
The win was an historic one for Samoa as it is the first time that they have beaten Scotland at Test level.
In the first game between these sides since the 2011 Rugby World Cup Final at the same venue, the All Blacks outscored their visitors two tries to one but were pushed all the way by a French side showing a marked improvement on their woeful Six Nations campaign.
The Sudamerica XV - representing the CONSUR nations - scored three tries of their own as England blew hot and cold.
Eight tries from the Lions including doubles from Mike Phillips and Alex Cuthbert set them on the road to success as encouraging moments were mixed with multiple handling errors — the Lions coming into their own to produce an excellent second half.
France battled to a 23-16 win over Scotland on a wet night in Paris in the final match of the 2013 Six Nations.
It was the perfect send-off for Italian prop Andrea Lo Cicero as the Azzurri finish the Championship in fourth, above the struggling Irish and French.
Two tries from Alex Cuthbert, who ends with four scores to his name, proved to be the turning point in the game after a first-half that ended try-less.
Six penalties from Toby Flood kept England ahead on the scoreboard as Italy recovered from a 15-3 deficit at the start of the second half to leave Twickenham on edge in a dramatic finish.
The Toulouse man's try six minutes from time, converted by Frederic Michalak, ensured the French ended their run of three straight defeats.
A match dominated more by the whistle and boot than any real memorable moments of attacking flair, Scotland and Wales racked up a total of 28 penalties between them as both sides continued to displease referee Craig Joubert.
It's the first time since 2001 that the Scots have won back-to-back Six Nations matches.
France were transformed from the sluggish side that were abysmal against Wales a fortnight ago — aggressive at the breakdown and benefiting from moving Wesley Fofana back into the centre after his ill-fated stint on the wing.
A severe downpour before kick-off hindered the handling ability of both sides through the first half, with Leigh Halfpenny adding three penalties for the visitors and Kristopher Burton responding with two for the hosts.