England were left frustrated by a resurgent Italian performance as the hosts kept their Grand Slam hopes alive with an 18-11 win.
Six penalties from Toby Flood kept England ahead on the scoreboard as Italy recovered from a 15-3 deficit at the start of the second half to leave Twickenham on edge in a dramatic finish.
The Azzurri resembled the side that were so impressive in their opening game of the championship against France — hounding England in defence and creating ample attacking opportunities in the second half against an opponent who they have never defeated.
Only desperate defence from England going into the final 10 minutes kept the hosts clinging on to the lead, with all thoughts of a first Grand Slam in a decade put firmly on hold.
England signalled their intent early on with a penalty from Toby Flood after just three minutes — the Leicester fly-half coming in for the injured Owen Farrell.
Mike Brown came close to the opening try after Luciano Orquera's kick was charged down, but the ball eluded him as he tried to make the grounding.
The hosts enjoyed all the possession throughout the opening minutes but were unable to find the opening try, Flood settling for another three points to leave England 6-0 up after 15 minutes.
Italy responded on their first visit to England's half with a penalty from Orquera after an effective driving maul, lifting the voices of the visiting fans. The Azzurri supporters grew even louder minutes later when Alessandro Zanni burst down the left touchline after Sergio Parisse's inside flick — only for the ball to be knocked on.
England's large swathes of possession created another try-scoring opportunity for the hosts, but Flood's attempted score was ruled out. Italy then lost scrum-half Edoardo Gori to the sin-bin for taking out Flood off the ball.
The hosts' power at the scrum was again capitalised on by Flood, who added a further three more points after a fine break from Brown to leave England 12-3 up going into the interval after a frustrating half for the home fans.
Another Flood penalty at the start of the second half extended the gap and left Italy chasing the scoreboard, Orquera responding with a penalty of his own after England collapsed at the scrum.
Care's sloppy box kick was then taken out of the air by Andrea Masi and Orquera's delicate chip across to the left wing was snapped up by Luke McLean to score in the corner.
Giovambattista Venditti then carried down the right touchline to leave English tacklers on the deck, but Orquera's resultant penalty attempt fell well wide to the right — failing to make the most of a passage of play where England lost control.
The introduction of Ben Youngs steadied Flood and England crept back to a seven-point advantage thanks to another penalty from the Leicester number 10.
Italy however continued to produce some of their best rugby in this year's championship, finding space down the left-hand side through McLean.
It meant that England were clinging on desperately to their lead as time ticked away, until a knock-on five metres from their own try line led to a collective sigh of relief from the 82,000 crowd.
Twickenham expected a thrashing — the humbled crowd left booing and counting their blessings.
Man of the Match: A whole host of Italian candidates to choose from in defeat, with Alessandro Zanni getting the nod ahead of his captain Parisse, Masi and winger McLean.
Moment of the Match: Courtney Lawes' crucial line-out steal with two minutes remaining that helped England ease the Italian pressure.
Villain of the Match: Starting his first Test for some time, Toby Flood may have kicked well off the tee but struggled to get England's backs firing.
The scorers:
For England:
Pens: Flood 6
For Italy:
Try: McLean
Pens: Orquera 2
Yellow Card: Gori
The teams:
England: 15 Alex Goode, 14 Chris Ashton, 13 Manu Tuilagi, 12 Brad Barritt, 11 Mike Brown, 10 Toby Flood, 9 Danny Care, 8 Tom Wood, 7 Chris Robshaw (c), 6 James Haskell, 5 Geoff Parling, 4 Joe Launchbury, 3 Dan Cole, 2 Tom Youngs, 1 Mako Vunipola.
Replacements: 16 Dylan Hartley, 17 David Wilson, 18 Joe Marler, 19 Courtney Lawes, 20 Tom Croft, 21 Ben Youngs, 22 Freddie Burns, 23 Billy Twelvetrees.
Italy: 15 Andrea Masi, 14 Giovambattista Venditti, 13 Gonzalo Canale, 12 Gonzalo Garcia, 11 Luke McLean, 10 Luciano Orquera, 9 Edoardo Gori, 8 Sergio Parisse, 7 Robert Barbieri, 6 Alessandro Zanni, 5 Joshua Furno, 4 Quintin Geldenhuys, 3 Martin Castrogiovanni, 2 Leonardo Ghiraldini (c) 1 Alberto De Marchi.
Replacements: 16 Davide Giazzon, 17 Andrea Lo Cicero, 18 Lorenzo Cittadini, 19 Antonio Pavanello, 20 Francesco Minto, 21 Simone Favaro, 22 Tobias Botes, 23Tommaso Benvenuti.
Referee: George Clancy (Ireland)
Assistant referees: Nigel Owens (Wales), Mathieu Raynal (France)
Television match official: Simon McDowell (Ireland)
The Toulouse man's try six minutes from time, converted by Frederic Michalak, ensured the French ended their run of three straight defeats.
A match dominated more by the whistle and boot than any real memorable moments of attacking flair, Scotland and Wales racked up a total of 28 penalties between them as both sides continued to displease referee Craig Joubert.
It's the first time since 2001 that the Scots have won back-to-back Six Nations matches.
France were transformed from the sluggish side that were abysmal against Wales a fortnight ago — aggressive at the breakdown and benefiting from moving Wesley Fofana back into the centre after his ill-fated stint on the wing.
A severe downpour before kick-off hindered the handling ability of both sides through the first half, with Leigh Halfpenny adding three penalties for the visitors and Kristopher Burton responding with two for the hosts.
Stuart Lancaster's outfit put in another mature effort that leaves them as the last remaining unbeaten side in the 2013 Championship.
A solitary late try from wing George North handed Wales the spoils in a dour game that culminated to the sound of boos and whistles from the Parisian crowd.
Four tries, including a brilliant length of the field interception try from Stuart Hogg, led to a memorable victory for Scotland in front of a vocal home crowd at Murrayfield, compensating for the performance against England at Twickenham last weekend.
It was a sensational victory for the Azzurri who have now managed to beat Les Bleus twice in the last two years following their famous win in 2011.
The hosts enjoyed large portions of possession in both halves and arguably should have come away with more points, despite racking up four tries through Chris Ashton, debutant Billy Twelvetrees, Geoff Parling and Danny Care.
A dire performance from Wales in the opening 40 minutes left them with a mountain to climb in the second-half, at which they threw everything to bounce back from a 30-3 scoreline to 30-22 in an utterly dominant half.
The loss meant that Wales, the current Grand Slam champions and World Cup semi-finalists, fell out of the top-eight seeds for RWC 2015, the draw for which takes place on Monday.
New Zealand responded to a 15-0 defecit with scores from Julian Savea and Kieran Read, before England took charge thanks to three of their own from Brad Barritt, Chris Ashton and Manu Tuilagi in an astonishing second-half performance.
The visitors crossed the whitewash on five occasions with Wyles bagging a brace, while Andrew Suniula, Paul Emerick and Takudzwa Ngwenya also added their name to the scoresheet.
Three penalties from Pat Lambie and a bizarre try from Willem Alberts handed the visitors the win, with Toby Flood and Owen Farrell accumulating five penalties between them.
Ireland led from start to finish in a dominant display, outscoring their visitors seven tries to two.
Unlike their convincing successes over Australia and Argentina this month, victory didn't come easily for the French, who were trailing the Islanders going into the final quarter.
Predictions the All Blacks' attack would incinerate Wales' defence came to fruition in the first half especially. However even though the scoreline may read otherwise, it was a much better effort from the Welsh - the second half especially.